NAD⁺ 500MG
Original price was: $89.99.$49.00Current price is: $49.00.MG
In stock
Overview
Nicotinamide Adenine Dinucleotide (NAD+) is arguably the most important molecule you’ve never heard of. Present in every cell of every living organism, NAD+ is like the currency of cellular energy – without it, life as we know it would cease to exist. This coenzyme doesn’t just participate in energy production; it’s a critical player in DNA repair, gene expression, immune function, and the aging process itself. The discovery that NAD+ levels decline with age has sparked intense research interest in its potential for extending healthspan and lifespan.
Key Characteristics
MOLECULAR PROFILE
- Formula: C21H27N7O14P2
- Weight: 663.43 g/mol
- CAS: 53-84-9
- Structure: Dinucleotide
PHYSICAL PROPERTIES
- Form: White lyophilized powder
- Solubility: Highly water-soluble
- Stability: Light and heat sensitive
- Storage: Keep refrigerated 36‑46 °F (2‑8 °C), protect from light
How It Works
NAD+ operates as a master regulator of cellular function through multiple mechanisms:
Primary Functions
Redox Reactions
Shuttles electrons in over 400 enzymatic reactions throughout the cell.
Sirtuin Activation
Fuels sirtuins, the “longevity proteins” that regulate aging processes.
PARP Activation
Powers DNA repair enzymes called PARPs for genomic stability.
Metabolic Effects
Energy Metabolism
Essential for converting nutrients into ATP through glycolysis and the citric acid cycle.
Fatty Acid Oxidation
Critical for fat metabolism and oxidative phosphorylation.
Calcium Signaling
CD38 substrate involved in calcium signaling and immune function.
Research Findings
The research on NAD+ has revealed its profound impact on health and aging across multiple biological systems.
Longevity and Aging
- Extended lifespan in yeast, worms, and mice models
- Restoration of youthful cellular function
- Improved mitochondrial health with age
- Enhanced DNA repair capacity
- Reduced cellular senescence
- Protection against age-related diseases
Metabolic Health
- Enhanced insulin sensitivity
- Improved glucose metabolism
- Better lipid profiles
- Increased metabolic flexibility
- Protection against metabolic syndrome
- Reduced inflammation markers
Cardiovascular Benefits
- Improved cardiac function
- Enhanced blood vessel elasticity
- Protection against heart failure
- Reduced atherosclerosis
- Better blood pressure regulation
- Improved endothelial function
Neuroprotection
- Protection against neurodegeneration
- Improved cognitive function
- Enhanced memory and learning
- Reduced risk of Alzheimer’s pathology
- Better neuronal energy metabolism
- Protection against stroke damage
DNA Repair and Cancer Prevention
- Enhanced DNA damage repair
- Reduced mutation accumulation
- Protection against UV damage
- Improved chromosomal stability
- Potential cancer prevention properties
- Protection against stroke damage
Immune Function
- Enhanced T-cell function
- Better inflammatory regulation
- Improved response to infections
- Reduced chronic inflammation
- Better immune surveillance
Exercise Performance
- Enhanced mitochondrial biogenesis
- Improved muscle function
- Better exercise capacity
- Faster recovery times
- Increased endurance
Potential Side Effects in Research
Flushing
Temporary skin flushing at high doses
Headache
Rare reports of mild headaches
Itching
Mild pruritis in some subjects
Liver Concerns
Very high doses may affect liver enzymes
Gastrointestinal
Occasional mild GI discomfort
Generally Safe
Well-tolerated at physiological doses
Overall safety profile appears favorable across multiple research studies and model systems.
References
- Reiten OK, et al. “Therapeutic targeting of NAD+ metabolism in mitochondrial disease.” Cell. 2023.
- Covarrubias AJ, et al. “NAD+ metabolism and its roles in cellular processes during ageing.” Nat Rev Mol Cell Biol. 2021.
- Abdellatif M, et al. “NAD+ metabolism and cardiovascular diseases.” Nature Cardiovascular Research. 2024.
- Sharma A, et al. “NAD+ boosting reverses vascular aging in mice.” Nature Aging. 2023.
- Li C, et al. “NAD+ enhances mitochondrial function and longevity pathways.” Science. 2024.
- Dall M, et al. “NAD+ and metabolic regulation of age-related proteostasis.” Nature Metabolism. 2023.
- Lautrup S, et al. “NAD+ in Brain Aging and Neurodegenerative Disorders.” Cell Metab. 2019.
- Reiten OK, et al. “Preclinical and clinical evidence of NAD+ precursors.” Nat Aging. 2021.
- Kane AE, Sinclair DA. “Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.” Circ Res. 2018.
- Navas LE, Carnero A. “NAD+ metabolism, stemness, the immune response, and cancer.” Signal Transduct Target Ther. 2021.
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